Biotin and derivatives
Medchemexpress LLC L-biotin (unnatural enantiomer of biotin) | 21788-37-4 | MFCD22373639 | 99.5% | 244.31 g·mol⁻¹ | C10H16N2O3S | 1 ML
L-biotin is the unnatural enantiomer of biotin supplied as a research reagent. It binds streptavidin in vitro and is provided as a ready-to-use 10 mM solution in DMSO (1 mL) or as solid powder in multiple pack sizes. Recommended storage conditions are -20°C for powder, and -80°C for stock solutions (up to 6 months).
- Unnatural enantiomer of biotin
- Binds streptavidin in vitro
- Available as 10 mM DMSO solution or solid powder
- High purity (>99%)
- Soluble in DMSO at high concentration
- Powder storage: -20°C; stock solution storage: -80°C (6 months)
Medchemexpress LLC CD79B Human Biotin 100ug
Recombinant human CD79B (extracellular residues Ala29-Asp159) produced in HEK293 cells and enzymatically biotinylated via an Avi tag. The construct includes a C-terminal His-Avi fusion, is >95% pure, and migrates ~35-45 kDa on SDS-PAGE due to glycosylation. Supplied with storage and reconstitution guidance for use in immobilization and binding assays.
- Site-specific biotinylation for consistent immobilization.
- C-terminal His-Avi tag for purification and controlled biotinylation.
- Mammalian expression preserves native glycosylation and folding.
- High purity suitable for ELISA, SPR/BLI, and flow cytometry.
- Storage and reconstitution recommendations to maintain activity.
Medchemexpress LLC Undecanoic acid, biotinyl N-hydroxysuccinimide ester | 887628-40-2 | MFCD05865045 | 99.5% | C25H40N4O6S | 10MG
Biotin-C10-NHS Ester is an alkyl/ether-based PROTAC linker that provides an NHS-activated biotinylation reagent for conjugation to primary amines. It is intended for research use in chemical synthesis and bioconjugation workflows, enabling introduction of a biotin affinity tag for purification and detection; follow the manufacturer datasheet and COA for handling and storage instructions.
- NHS-activated ester for efficient amine coupling.
- 10-carbon spacer to reduce steric hindrance during binding.
- Introduces a biotin tag for affinity purification and detection.
- High purity suitable for synthetic and analytical applications.
- Supplied with datasheet and certificate of analysis for quality verification.
Medchemexpress LLC m-PEG14-NHS ester | 95.0% | 773.86 | 25 MG
m-PEG14-NHS ester is a PEG-based PROTAC linker. This chemical is intended for laboratory use in the synthesis of PROTACs.
- Supplied as a white to off-white solid
- Stable under recommended storage conditions
- Recommended storage at -20°C, sealed storage, away from moisture and light
- Shipping at room temperature if less than 2 weeks
- Has a purity of 95.0%
- Molecular weight is 773.86
Medchemexpress LLC Mal-PEG8-NHS ester | 2055033-05-9 | 98.96% | 25 MG
Mal-PEG8-NHS ester is a PEG-based PROTAC linker designed for the synthesis of PROTACs. This compound is for research use only and aids in the development of PROTACs, which exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Can be used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- For research use only
Medchemexpress LLC 2,5-dioxopyrrolidin-1-yl 3-(pyridin-2-yldisulfanyl)butanoate | 107348-47-0 | MFCD28398150 | 98.0% | 326.40 g/mol | C13H14N2O4S2 | 50 MG
PPC-NHS ester is a cleavable linker reagent containing an N-hydroxysuccinimide (NHS) ester and a pyridin-2-yldisulfanyl cleavable moiety; it is used to attach cytotoxic payloads to antibodies and enable payload release under reducing conditions.
- Cleavable disulfide linker enabling intracellular release of payloads
- N-hydroxysuccinimide (NHS) ester reactive toward primary amines
- Molecular formula C13H14N2O4S2, molecular weight 326.40 g/mol
- Purity 98.0%
- Supplied as a white to off-white solid, 50 MG per package
- Storage: powder -20°C (stable 3 years); in solvent -80°C (6 months), -20°C (1 month)
Medchemexpress LLC Diazo biotin-PEG3-azide | 1339202-33-3 | MFCD28334530 | 95.5% | C33H45N9O7S | 10MG
Diazo biotin-PEG3-azide is a multifunctional PEG3 linker combining a cleavable diazo functional group, a biotin affinity tag, and an azide reactive handle. It is designed for efficient biotinylation and capture of alkyne-bearing biomolecules using click chemistry and for use as a linker in chemical biology workflows.
- Provides azide functionality for CuAAC and SPAAC click reactions.
- Includes a biotin tag for affinity purification and detection.
- Contains a diazo group enabling photo-cleavage or crosslinking.
- PEG3 spacer improves solubility and reduces steric hindrance.
- Suitable for biotinylation, pull-down assays, and linker synthesis.
Medchemexpress LLC (+)-Biotin 4-nitrophenyl ester | 33755-53-2 | ≥98.0% | 250 MG
(+)-Biotin-ONP is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Alkyl chain-based PROTAC linker
- Can be used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- For research use only
![eMolecules 58-85-5 | Biotin | Ambeed | MFCD00005541 | 244.310 | C10H16N2O3S | 98.000 | OC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12 | 25g | 490500208](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000471012.jpg-250.jpg)
eMolecules 58-85-5 | Biotin | Ambeed | MFCD00005541 | 244.310 | C10H16N2O3S | 98.000 | OC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12 | 25g | 490500208
Biotin | Ambeed | 58-85-5 | MFCD00005541 | 244.310 | C10H16N2O3S | 98.000 | OC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12 | 25g | 490500208
![eMolecules 58-85-5 | D-Biotin | Oakwood Chemicals | MFCD00005541 | 244.310 | C10H16N2O3S | 99.000 | OC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12 | 5g | 480169794](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000160341.jpg-250.jpg)
eMolecules 58-85-5 | D-Biotin | Oakwood Chemicals | MFCD00005541 | 244.310 | C10H16N2O3S | 99.000 | OC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12 | 5g | 480169794
D-Biotin | Oakwood Chemicals | 58-85-5 | MFCD00005541 | 244.310 | C10H16N2O3S | 99.000 | OC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12 | 5g | 480169794
Medchemexpress LLC Biotin-C5-Azide (DecarboxyBiotin-N3) | 1260586-88-6 | C10H17N5OS | 25 MG
Biotin-C5-Azide (DecarboxyBiotin-N3) is a versatile biotin reagent designed for preparing biotinylated conjugates. It functions as a click chemistry reagent, featuring an azide group that enables participation in various cycloaddition reactions.
- Can be used to prepare biotinylated conjugates
- Click chemistry reagent containing an azide group
- Undergoes copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing alkyne groups
- Participates in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups
Medchemexpress LLC 3H-indolium inner salt (TEA), N-hydroxysuccinimide ester | 1620475-28-6 | 95.0% | 1043.25 | C45H62N4O16S4 | 10 MG
Alexa Fluor 647 NHS ester (TEA) is a far-red, photostable succinimidyl ester dye supplied as the triethylammonium (TEA) salt for covalent labeling of primary amines on proteins, peptides, and amine-modified oligonucleotides. It produces strong fluorescence suitable for fluorescence imaging, flow cytometry, and other fluorescence-based assays. The product is supplied as a blue to dark blue solid and is sensitive to moisture and light.
- Reactive succinimidyl ester for covalent labeling of primary amines.
- Far-red fluorescence compatible with 633-647 nm excitation for imaging and flow cytometry.
- Photostable with high signal intensity for prolonged imaging.
- Suitable for labeling proteins, peptides, and amine-modified oligonucleotides.
- Supplied as a blue to dark blue solid in TEA salt form; store sealed, away from moisture and light.
Medchemexpress LLC m-PEG6-NHS ester | 1449390-12-8 | ≥97.0% | 421.44 g·mol⁻¹ | C18H31NO10 | 50 MG
m-PEG6-NHS ester is a non-cleavable 6-unit polyethylene glycol (PEG) linker terminating in an activated N-hydroxysuccinimide (NHS) ester; it is used for amide coupling to amines in the synthesis of antibody-drug conjugates and PROTACs.
- Purity: ≥97.0%.
- Molecular weight: 421.44 g·mol⁻¹.
- Chemical formula: C18H31NO10.
- CAS number: 1449390-12-8.
- Form: liquid, colorless to light yellow; density ~1.21 g/cm³.
- Storage: pure form -20 °C (3 years) or 4 °C (2 years); in solvent -80 °C (6 months) or -20 °C (1 month).
- Applications: non-cleavable PEG6 linker for ADC synthesis; PEG/alkyl/ether-based PROTAC linker.
- Packaging: commonly available in 100 MG, 250 MG, 1 G, and 5 G; larger quantities available by quote; a 50 MG pack is indicated in supplier data but on the manufacturer page.
Medchemexpress LLC M-PEG13-NHS ester | 3063847-98-0 | 95.0% | C32H59NO17 | 50 MG
M-PEG13-NHS ester is a PEG-based PROTAC linker. It is utilized in the synthesis of PROTACs, which are molecules designed to exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Can be used in the synthesis of PROTACs
- PROTACs contain two different ligands connected by a linker
- One ligand targets an E3 ubiquitin ligase, and the other targets the protein of interest
- Exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins
Apexbio Technology LLC Biotin-11-dUTP(Synonyms: Biotin-11-deoxyuridine triphosphate, Biotin-11-dUTP lithium salt), 10ul (5 mM), CAS: 1221498-88-9.
Biotin-11-dUTP (CAS 1221498-88-9) is a biotin-conjugated analogue of deoxythymidine triphosphate (dTTP) that can be incorporated enzymatically into DNA or cDNA sequences during polymerase reactions After integration labeled nucleic acid fragments can be detected using streptavidin coupled to horseradish peroxidase (HRP) alkaline phosphatase (AP) fluorescent molecules or bead-based capture systems This approach is frequently utilized in polymerase chain reaction (PCR) nick translation reverse transcription assays and apoptosis studies facilitating DNA probe labeling and molecular analysis workflows